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Heterocyclic compounds have a wide range of applications and properties. They are often antimicrobial agents, can inhibit specific enzymes, and are generally useful in organic synthesis. This experiment provides instructors with a variety of heterocyclic compounds that can be synthesized quickly with the aid of microwaves. While not a lot of Microwave-Assisted Organic Synthesis (MAOS) is taught at the undergraduate level, it has the advantages of generally increasing yields, decreased reaction times, and, in most cases, eliminating the need for a solvent.
The heterocyclic chemistry includes the synthesis of compounds such as phthalamide, succinic anhydride and benzoxazinone. This experiment would fit well into a course when discussing green chemistry, heterocyclic chemistry, esters, amides, anhydrides, amines, carboxylic acids, melting points and recrystallization.
The supplemental information includes a list of necessary chemicals and equipment, a student handout, procedures, and melting point data for all products.
Summary prepared October 2008 by Douglas M. Young at the University of Oregon.
Musiol, R.; Tyman-Szram, B.; Polanski, J. J. Chem. Educ., Print 2006, 83, pp 632-633.