Adaptation of phase vanishing reactions and solid-solid reactions to undergraduate organic chemistry laboratory

Veljko Dragojlovic, Oceanographic Center, Oceanographic Center, Nova Southeastern University, 8000 North Ocean Drive, Dania, FL 33004

Power Point Presentation (PDF)

Laboratory Experiment #1 (PDF)

Laboratory Experiment #2 (PDF)

ABSTRACT: Phase vanishing reactions are triphasic reactions, which involve a reagent, a fluorous solvent and a substrate. In the course of the reaction the reagent disappears ("vanishes") and the product is separated from the fluorous solvent by filtration. The solvent can be reused. In a solid-solid reaction, two solid reactants are mixed together. Sometimes mixing of the two solids (e.g. an aldehyde and an amine) results in formation of a liquid phase which, upon completion of the reaction, solidifies to give the product. Both "phase vanishing" halogenation reactions as well as solid-solid synthesis of imines have been adapted for an introductory organic chemistry laboratory. Presentation will include a discussion of suitable substrates for each of the exercises, potential problems as well as discussion of students' results and students' feedback.